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Target
DNA-binding protein Ikaros
Ligand
BDBM526278
Substrate
n/a
Meas. Tech.
Prolabel Quantification of IKZF1, IKZF2, or GSPT1 Protein Levels in 293GT Cells
EC50
570±n/a nM
Citation
 Beckwith, RE; Bonazzi, S; Cernijenko, A; Ma, F; Ware, NF 3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof US Patent  US11185537 Publication Date 11/30/2021 
Target
Name:
DNA-binding protein Ikaros
Synonyms:
DNA-binding protein Ikaros | IK1 | IKAROS | IKZF1 | IKZF1_HUMAN | Ikaros family zinc finger protein 1 | LYF1 | Lymphoid transcription factor LyF-1 | ZNFN1A1
Type:
PROTEIN
Mol. Mass.:
57528.78
Organism:
Homo sapiens
Description:
ChEMBL_120150
Residue:
519
Sequence:
MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS
  
Inhibitor
Name:
BDBM526278
Synonyms:
3-(4-fluoro-5-(methyl((1S,2S)-2- (methylamino)cyclohexyl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6-dione | US11185537, Compound I-163
Type:
Small organic molecule
Emp. Form.:
C21H27FN4O3
Mol. Mass.:
402.4625
SMILES:
CN[C@H]1CCCC[C@@H]1N(C)c1ccc2C(=O)N(Cc2c1F)C1CCC(=O)NC1=O |r|
Structure:
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