Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM530474
Substrate
n/a
EC50
8.00±n/a nM
Citation
 L., PH; A., JJ; V., DS AMINOIMIDAZOLE FPR2 AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM530474
Synonyms:
WO2022076764, Example 3
Type:
Small organic molecule
Emp. Form.:
C25H19F4N3O4
Mol. Mass.:
501.4297
SMILES:
COc1cccc(c1)-c1cn(c(NC(=O)c2ccc(OC(F)F)cc2)n1)-c1c(F)cc(OC)cc1F |(-7.65,1.94,;-6.41,1.04,;-5,1.66,;-4.84,3.19,;-3.43,3.82,;-2.19,2.91,;-2.35,1.38,;-3.75,.76,;-1.1,.48,;-1.1,-1.06,;.36,-1.54,;1.27,-.29,;2.81,-.29,;3.58,1.04,;2.81,2.38,;5.12,1.04,;5.89,-.29,;7.43,-.29,;8.2,1.04,;9.74,1.04,;10.51,2.38,;9.74,3.71,;12.05,2.38,;7.43,2.38,;5.89,2.38,;.36,.95,;.84,-3,;-.19,-4.15,;-1.7,-3.83,;.28,-5.61,;1.79,-5.93,;2.27,-7.4,;1.24,-8.54,;2.82,-4.79,;2.35,-3.32,;3.38,-2.18,)|
Structure:
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