Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM530483
Substrate
n/a
EC50
15±n/a nM
Citation
 L., PH; A., JJ; V., DS AMINOIMIDAZOLE FPR2 AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM530483
Synonyms:
WO2022076764, Example 12
Type:
Small organic molecule
Emp. Form.:
C24H16ClF4N3O3
Mol. Mass.:
505.849
SMILES:
COc1cc(F)c(c(F)c1)-n1cc(nc1NC(=O)c1ccc(OC(F)F)cc1)-c1cccc(Cl)c1 |(1.24,-8.54,;2.27,-7.4,;1.79,-5.93,;.28,-5.61,;-.19,-4.15,;-1.7,-3.83,;.84,-3,;2.34,-3.32,;3.38,-2.18,;2.82,-4.79,;.36,-1.54,;-1.1,-1.06,;-1.1,.48,;.36,.95,;1.27,-.29,;2.81,-.29,;3.58,1.04,;2.81,2.38,;5.12,1.04,;5.89,-.29,;7.43,-.29,;8.2,1.04,;9.74,1.04,;10.51,2.38,;9.74,3.71,;12.05,2.38,;7.43,2.38,;5.89,2.38,;-2.35,1.38,;-3.75,.76,;-5,1.66,;-4.84,3.19,;-3.43,3.82,;-3.27,5.35,;-2.19,2.92,)|
Structure:
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