Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM530533
Substrate
n/a
EC50
32±n/a nM
Citation
 L., PH; A., JJ; V., DS AMINOIMIDAZOLE FPR2 AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM530533
Synonyms:
WO2022076764, Example 62
Type:
Small organic molecule
Emp. Form.:
C22H16F4N6O4
Mol. Mass.:
504.3939
SMILES:
COc1cc(F)c(c(F)c1)-n1cc(nc1NC(=O)c1ccc(OC(F)F)cc1)C(=O)Nc1cn[nH]c1 |(1.23,-8.54,;2.26,-7.39,;1.79,-5.93,;2.82,-4.79,;2.34,-3.32,;3.37,-2.18,;.84,-3,;-.19,-4.14,;-1.7,-3.82,;.28,-5.61,;.36,-1.53,;-1.1,-1.06,;-1.1,.48,;.36,.96,;1.26,-.29,;2.81,-.29,;3.58,1.04,;2.81,2.38,;5.12,1.04,;5.89,-.29,;7.43,-.29,;8.2,1.04,;9.74,1.04,;10.51,2.38,;9.74,3.71,;12.05,2.38,;7.43,2.38,;5.89,2.38,;-2.35,1.39,;-2.19,2.92,;-3.76,.76,;-5,1.66,;-6.47,1.19,;-7.37,2.43,;-6.47,3.68,;-5,3.2,)|
Structure:
Search PDB for entries with ligand similarity: