Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM530539
Substrate
n/a
EC50
45±n/a nM
Citation
 L., PH; A., JJ; V., DS AMINOIMIDAZOLE FPR2 AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM530539
Synonyms:
WO2022076764, Example 68
Type:
Small organic molecule
Emp. Form.:
C26H26F4N4O5
Mol. Mass.:
550.5021
SMILES:
COc1cc(F)c(c(F)c1)-n1cc(nc1NC(=O)c1ccc(OC(F)F)cc1)C1CCN(CC1)C(=O)CCO |(1.23,-8.54,;2.26,-7.39,;1.79,-5.93,;.28,-5.61,;-.19,-4.14,;-1.7,-3.82,;.84,-3,;2.34,-3.32,;3.37,-2.18,;2.82,-4.79,;.36,-1.53,;-1.1,-1.06,;-1.1,.48,;.36,.96,;1.26,-.29,;2.81,-.29,;3.58,1.04,;2.81,2.38,;5.12,1.04,;5.89,-.29,;7.43,-.29,;8.2,1.04,;9.74,1.04,;10.51,2.38,;9.74,3.71,;12.05,2.38,;7.43,2.38,;5.89,2.38,;-2.35,1.39,;-2.19,2.92,;-3.44,3.82,;-4.84,3.2,;-5,1.66,;-3.76,.76,;-6.09,4.1,;-5.93,5.63,;-7.49,3.47,;-8.74,4.38,;-10.15,3.75,)|
Structure:
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