Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM530546
Substrate
n/a
EC50
23±n/a nM
Citation
 L., PH; A., JJ; V., DS AMINOIMIDAZOLE FPR2 AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM530546
Synonyms:
N-( 1-(2,6-Difluoro-4-methoxyphenyl)-4-(2-azaspiro[3.3 ]heptan-6-yl)-1H-imidazol-2-yl)-4-(difluoromethoxy)benzamide | WO2022076764, Example 75
Type:
Small organic molecule
Emp. Form.:
C25H24F4N4O3
Mol. Mass.:
504.4767
SMILES:
COc1cc(F)c(c(F)c1)-n1cc(CC2CC3(CNC3)C2)nc1NC(=O)c1ccc(OC(F)F)cc1 |(-3.75,11.57,;-2.5,10.67,;-2.66,9.14,;-1.42,8.23,;-1.58,6.7,;-.33,5.79,;-2.99,6.07,;-4.23,6.98,;-5.64,6.35,;-4.07,8.51,;-3.15,4.54,;-2,3.51,;-2.63,2.1,;-1.86,.77,;-.32,.77,;.77,1.86,;1.86,.77,;2.95,1.86,;4.04,.77,;2.95,-.32,;.77,-.32,;-4.16,2.26,;-4.48,3.77,;-5.89,4.4,;-7.13,3.49,;-6.97,1.96,;-8.54,4.12,;-9.79,3.21,;-11.19,3.84,;-11.35,5.37,;-12.76,6,;-12.92,7.53,;-14.33,8.16,;-11.68,8.43,;-10.11,6.28,;-8.7,5.65,)|
Structure:
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