Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM530552
Substrate
n/a
EC50
4.00±n/a nM
Citation
 L., PH; A., JJ; V., DS AMINOIMIDAZOLE FPR2 AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM530552
Synonyms:
WO2022076764, Example 81
Type:
Small organic molecule
Emp. Form.:
C22H20F4N4O3
Mol. Mass.:
464.4128
SMILES:
COc1cc(F)c(c(F)c1)-n1cc(nc1NC(=O)c1ccc(OC(F)F)cc1)C1CC(N)C1 |(-8.66,3.08,;-7.13,2.92,;-6.5,1.51,;-4.97,1.35,;-4.34,-.06,;-2.81,-.22,;-5.25,-1.3,;-6.78,-1.14,;-7.69,-2.39,;-7.41,.27,;-4.62,-2.71,;-3.11,-3.03,;-2.95,-4.56,;-4.36,-5.19,;-5.39,-4.04,;-6.92,-4.2,;-7.55,-5.61,;-6.64,-6.86,;-9.08,-5.77,;-9.71,-7.18,;-11.24,-7.34,;-12.14,-6.09,;-13.68,-6.26,;-14.3,-7.66,;-13.4,-8.91,;-15.83,-7.82,;-11.52,-4.69,;-9.99,-4.53,;-1.62,-5.33,;-.13,-4.93,;.27,-6.42,;1.6,-7.19,;-1.22,-6.82,)|
Structure:
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