Reaction Details Report a problem with these data
Target
N-formyl peptide receptor 2
Ligand
BDBM530554
Substrate
n/a
EC50
400±n/a nM
Citation
 L., PH; A., JJ; V., DS AMINOIMIDAZOLE FPR2 AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
N-formyl peptide receptor 2
Synonyms:
ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38968.35
Organism:
Homo sapiens (Human)
Description:
P25090
Residue:
351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
  
Inhibitor
Name:
BDBM530554
Synonyms:
N-[l-(2,6-Ddifluoro-4-methoxyphenyl)-4-(3-methanesulfonamidocyclobutyl)-1H-imidazol-2-yl]-4-(difluorom ethoxy )benzamide | WO2022076764, Example 83
Type:
Small organic molecule
Emp. Form.:
C23H22F4N4O5S
Mol. Mass.:
542.503
SMILES:
COc1cc(F)c(c(F)c1)-n1cc(nc1NC(=O)c1ccc(OC(F)F)cc1)C1CC(C1)NS(C)(=O)=O |(-8.66,3.08,;-7.13,2.92,;-6.5,1.51,;-4.97,1.35,;-4.34,-.06,;-2.81,-.22,;-5.25,-1.3,;-6.78,-1.14,;-7.69,-2.39,;-7.41,.27,;-4.62,-2.71,;-3.11,-3.03,;-2.95,-4.56,;-4.36,-5.19,;-5.39,-4.04,;-6.92,-4.2,;-7.55,-5.61,;-6.64,-6.86,;-9.08,-5.77,;-9.71,-7.18,;-11.24,-7.34,;-12.14,-6.09,;-13.68,-6.26,;-14.3,-7.66,;-13.4,-8.91,;-15.83,-7.82,;-11.52,-4.69,;-9.99,-4.53,;-1.62,-5.33,;-.13,-4.93,;.27,-6.42,;-1.22,-6.82,;1.6,-7.19,;1.6,-8.73,;1.6,-10.27,;.27,-9.5,;2.93,-9.5,)|
Structure:
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