Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM530555
Substrate
n/a
Meas. Tech.
DGAT2 enzymatic activity assay
IC50
573±n/a nM
Citation
 Yeon-Hee, LR., AEJianming, BChen, CP., RJHelen, SE PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM530555
Synonyms:
(R)-1,3-bis(4-fluorophenyl)-N-(3-methyl-l,1-dioxidotetrahydrothiophen-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide | WO2022076495, EXAMPLE 1
Type:
Small organic molecule
Emp. Form.:
C25H21F2N3O4S
Mol. Mass.:
497.514
SMILES:
C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2n(-c3ccc(F)cc3)c(=O)n(-c3ccc(F)cc3)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: