Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM530570
Substrate
n/a
Meas. Tech.
DGAT2 enzymatic activity assay
IC50
32±n/a nM
Citation
 Yeon-Hee, L; R., AE; Jianming, B; Chen, C; P., RJ; Helen, SE PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM530570
Synonyms:
WO2022076495, EXAMPLE 16 | WO2022076495, EXAMPLE 21
Type:
Small organic molecule
Emp. Form.:
C22H25FN4O5S
Mol. Mass.:
476.521
SMILES:
CCOc1cc(c(F)cn1)-n1c2ccc(cc2n(C(C)C)c1=O)C(=O)NC1(C)CS(=O)(=O)C1 |(-1.14,11.09,;.37,10.77,;.84,9.31,;-.19,8.16,;.29,6.7,;-.74,5.55,;-2.25,5.87,;-3.28,4.73,;-2.73,7.34,;-1.7,8.48,;-.27,4.09,;1.2,3.61,;2.53,4.38,;3.86,3.61,;3.86,2.07,;2.53,1.3,;1.2,2.07,;-.27,1.6,;-.74,.13,;-2.25,-.19,;.29,-1.01,;-1.17,2.84,;-2.71,2.84,;5.2,1.3,;5.2,-.24,;6.53,2.07,;7.87,1.3,;7.1,-.03,;8.64,2.64,;9.97,1.87,;10.74,3.2,;11.3,1.1,;9.2,.53,)|
Structure:
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