Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM530650
Substrate
n/a
Meas. Tech.
DGAT2 enzymatic activity assay
IC50
6.30±n/a nM
Citation
 Yeon-Hee, L; R., AE; Jianming, B; Chen, C; P., RJ; Helen, SE PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM530650
Synonyms:
WO2022076495, EXAMPLE 81
Type:
Small organic molecule
Emp. Form.:
C23H24F3N3O5S
Mol. Mass.:
511.514
SMILES:
CC(C)n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)N[C@@]1(C)CCS(=O)(=O)C1 |wU:27.29,wD:27.30,(.14,1.73,;1.65,1.41,;2.68,2.55,;2.13,-.06,;3.59,-.53,;4.92,.24,;6.26,-.53,;6.26,-2.07,;4.92,-2.84,;3.59,-2.07,;2.13,-2.55,;1.65,-4.01,;2.68,-5.16,;2.2,-6.62,;3.23,-7.77,;2.76,-9.23,;3.79,-10.38,;1.25,-9.55,;.7,-6.94,;-.33,-5.8,;.14,-4.33,;-.89,-3.19,;1.22,-1.3,;-.32,-1.3,;7.59,.24,;8.93,-.53,;7.59,1.78,;8.93,2.55,;9.55,1.14,;8.02,3.79,;8.93,5.04,;10.39,4.56,;10.71,6.07,;11.92,4.4,;10.39,3.02,)|
Structure:
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