Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM530752
Substrate
n/a
IC50
407±n/a nM
Citation
 Yeon-Hee, L; Jianming, B; P., RJ; Yeon-Hee, L; Jianming, B; P., RJ PREPARATION OF OXINDOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM530752
Synonyms:
WO2022076496, Example 49
Type:
Small organic molecule
Emp. Form.:
C27H29F5N2O3
Mol. Mass.:
524.5228
SMILES:
CCC1(CCC(CC1)NC(=O)c1ccc2N(C(=O)C(C)(C)c2c1)c1cccc(OC(F)F)c1)C(F)(F)F |(10.52,-8.9,;11.8,-8.04,;11.69,-6.5,;11.59,-4.97,;10.2,-4.29,;8.93,-5.15,;9.03,-6.69,;10.42,-7.36,;7.59,-4.38,;7.59,-2.84,;8.93,-2.07,;6.26,-2.07,;6.26,-.53,;4.92,.24,;3.59,-.53,;2.13,-.06,;1.22,-1.3,;-.32,-1.3,;2.13,-2.55,;.79,-3.32,;2.75,-3.96,;3.59,-2.07,;4.92,-2.84,;1.65,1.41,;.14,1.73,;-.33,3.19,;.7,4.34,;2.2,4.02,;3.23,5.16,;4.74,4.84,;5.22,3.38,;5.77,5.99,;2.68,2.55,;13.08,-7.18,;13.18,-8.71,;14.35,-6.32,;14.46,-7.85,)|
Structure:
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