Target
PI3K/PI4K catalytic domain-containing protein
Ligand
BDBM533812
Substrate
n/a
IC50
550±n/a nM
Citation
 Michael, YJRobert, TMPeichao, L COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS WIPO 0:0 (2022) [PubMed] 
Target
Name:
PI3K/PI4K catalytic domain-containing protein
Synonyms:
PI3K/PI4K domain-containing protein
Type:
Protein
Mol. Mass.:
252626.40
Organism:
n/a
Description:
A0A0S4TH36
Residue:
2159
Sequence:
MSCGNKYFWNLEGHDPALALLDLFENGKKYNSLETLVDFLSKNIVLLENMKNNSNSKKEGLFNFLFLFQKLNGRPAENENPEPVPLLSLDLKLADTILVQKALLRDLVFLLGNREFDVFRRLYSLLIKFAPLDLKDLISIEKNHGSMICIYFTIYFSILLNIFGYENIGEFRKGEEIEELKLNWINKFVSQINDLLDYFIDKKTNLLRITDINNDCLILIFALILYLIISIIDIGNDKITEFKLAIIKLIKIQLSNLMFNYWYLKILLIIIERIGMDLTVSELVLVVLQYQKFIGEQSIKIENNNSFDKSMNKLGVFETHIVTHLCRTWVVKEITLKKQLMEFVEQFIFTYGKLKEKKFDDYFLKKEDDLSMLDPINIVFIKLVSLFSKAFGVSMTGIDKEEYKNKEISDSKEIDSLVLLNLLEELLQGRRSQKICGLILFDSIRMLVTVLTILVDHRNFESENYDIKREIIQNDLVIVNLHKGGWNLKAYKCIDLIEKLFEIITHLIIRYKEDHKELNNSVNTISSVSSSSTGSIFKTTSFDISLFLIVWKNYVTLITRKEYRTDPIIFNKSIHLISLYLVSRKYKLDMLCEITFPISEYSDNLPILLDERYSDLIDLWTILWRNYLNENTNLFYNKRDEVENIFTVPNINYFFEYLRILDQVITQNNGISSPGLALSDKESMYTQKFTTKVLELTGIISSILICHKIVHSSDRHNTLMAILSASENPRIMSEYIYKQATNSLQFDGAYIYNCLKFFREKWSSSIKIRVFSLISDLYISIMKQSLFQFIQCLLSNFSVRGGIFEKSFALFKVRGMRGIISEEDFEVLQQKLTNIFSYSNSDLDGDLTSSLIKNEIFFGCYSIDLYYTINNIQKGWQSPSLSITPSSPKTFLNKKRHSSLMITDSEDVYSIINRLNPLFDQLINDDDYLKLFMDTVGEISKCYFYFLFENKSSDSGERSLIDQISNFSTIFGVKFEDEKFMASMNLKNELLKNVNYSNPTEEVIVERFNYKFYSQLIIRMIYLCTWMIVDNNYESYKSLSDLFAEKILNGLFGISNDEGGNHTSSYKFSQGNDQFDRFKSSLTDDYVLEHYTKFVCIIWSIISSMDPESIYKSYIKILERESLSYYQLYILLVFLIESSDWFIHHGYFQHINLLKILRQVELMTCLSSAYLQVKDENKEKTSQINSSDLHLKILLVCLIQKSITVEISKEVPLECYKKKHPTILKTNHNDLDIPQIRIYKFNNKSNQRDAYINGGRSMISTSYFLSCRILPYLWSFYESYPTYKDIYTRLLQSSTQLTTYLDNLCVNLYETKNWQKMMNNFNNVHLESSVEIYDNRLIPYNQYIVLEYIWEYFINGNTMILIEKYISALIFSIYSSKKVGFFEVWLLLSLWKRYPARIYRHMMKTSSTWIVPFLMDHLIHYSILVKNNYIGISSPKNDLIRVFNNIELENTFSFLLYHYHPQYYHDRMSGKYFWYNASSEQGYLNKINSHNTEIKGLVMNCRYTQGNHQLVLQFHDYLHYIGHSLPFPVVIYLLSNQFSSEKKKFMSNSHHFHNYFHHSLYTSTLIVWSCVRSLLLSQESEWELLLLQYMEIIKSNKRNNQLVLTGLLDMALKSTRFSQILCIYTNNPNSPIMNIFQKSLFKECDFLLTCKSMKSSEENIERNEDQNMNGKYEKRNSSEIHGKGVINRLRTVQDSMEGLNLRMSSVSSLINKCFDTISETSENLNRSSLNILQFENKKHSLANVQFSFFYILCQLGEMAKYRNRKEGGLGLPIEEDDNPSALIGRLNSKEIAQLKSEIAQDLLAKIENVIQRKEYKNVPFLNTNMLKSSENKTKLLSIKKINKLKILQSAKNIPYLLSLQLTDHNSDNQDTLVDISKIEPEQDYEMTINLIVKCNDDCRQDVITMQYIHVFQKIFELYNIPVWLYPYRILPMMFKDINNSVIYGGIIEFIEDSISLHEIHELHSEGGLKAYYESTFGGKNSHIKKLENDNNVSYEQARYNFISSLAGYSIACYVLQIKDRHNGNILITKNGHIIHIDYGFIFDISPGNNLHFERAAFKVTQEMLDFMDDQVDLFDDLCLSGFLAVREHADLLLSLTQMLINSGIPCFRGETIKKLKERLLLNFSQQQASNIFSKKIHSAHNHITTKGYDLVQFIQQGIK
 
Inhibitor
Name:
BDBM533812
Synonyms:
2-Morpholinoethyl 2-chloro-5-(N-methyl-3-(4-(methylcarbamoyl)phenyl)pyrazolo[1,5- a]pyridine-5-carboxamido)benzoate | WO2022079616, Example 1.19
Type:
Small organic molecule
Emp. Form.:
C30H30ClN5O5
Mol. Mass.:
576.043
SMILES:
CNC(=O)c1ccc(cc1)-c1cnn2ccc(cc12)C(=O)N(C)c1ccc(Cl)c(c1)C(=O)OCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: