Target
PI3K/PI4K catalytic domain-containing protein
Ligand
BDBM533856
Substrate
n/a
IC50
>1000±n/a nM
Citation
 Michael, YJRobert, TMPeichao, L COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS WIPO 0:0 (2022) [PubMed] 
Target
Name:
PI3K/PI4K catalytic domain-containing protein
Synonyms:
PI3K/PI4K domain-containing protein
Type:
Protein
Mol. Mass.:
252626.40
Organism:
n/a
Description:
A0A0S4TH36
Residue:
2159
Sequence:
MSCGNKYFWNLEGHDPALALLDLFENGKKYNSLETLVDFLSKNIVLLENMKNNSNSKKEGLFNFLFLFQKLNGRPAENENPEPVPLLSLDLKLADTILVQKALLRDLVFLLGNREFDVFRRLYSLLIKFAPLDLKDLISIEKNHGSMICIYFTIYFSILLNIFGYENIGEFRKGEEIEELKLNWINKFVSQINDLLDYFIDKKTNLLRITDINNDCLILIFALILYLIISIIDIGNDKITEFKLAIIKLIKIQLSNLMFNYWYLKILLIIIERIGMDLTVSELVLVVLQYQKFIGEQSIKIENNNSFDKSMNKLGVFETHIVTHLCRTWVVKEITLKKQLMEFVEQFIFTYGKLKEKKFDDYFLKKEDDLSMLDPINIVFIKLVSLFSKAFGVSMTGIDKEEYKNKEISDSKEIDSLVLLNLLEELLQGRRSQKICGLILFDSIRMLVTVLTILVDHRNFESENYDIKREIIQNDLVIVNLHKGGWNLKAYKCIDLIEKLFEIITHLIIRYKEDHKELNNSVNTISSVSSSSTGSIFKTTSFDISLFLIVWKNYVTLITRKEYRTDPIIFNKSIHLISLYLVSRKYKLDMLCEITFPISEYSDNLPILLDERYSDLIDLWTILWRNYLNENTNLFYNKRDEVENIFTVPNINYFFEYLRILDQVITQNNGISSPGLALSDKESMYTQKFTTKVLELTGIISSILICHKIVHSSDRHNTLMAILSASENPRIMSEYIYKQATNSLQFDGAYIYNCLKFFREKWSSSIKIRVFSLISDLYISIMKQSLFQFIQCLLSNFSVRGGIFEKSFALFKVRGMRGIISEEDFEVLQQKLTNIFSYSNSDLDGDLTSSLIKNEIFFGCYSIDLYYTINNIQKGWQSPSLSITPSSPKTFLNKKRHSSLMITDSEDVYSIINRLNPLFDQLINDDDYLKLFMDTVGEISKCYFYFLFENKSSDSGERSLIDQISNFSTIFGVKFEDEKFMASMNLKNELLKNVNYSNPTEEVIVERFNYKFYSQLIIRMIYLCTWMIVDNNYESYKSLSDLFAEKILNGLFGISNDEGGNHTSSYKFSQGNDQFDRFKSSLTDDYVLEHYTKFVCIIWSIISSMDPESIYKSYIKILERESLSYYQLYILLVFLIESSDWFIHHGYFQHINLLKILRQVELMTCLSSAYLQVKDENKEKTSQINSSDLHLKILLVCLIQKSITVEISKEVPLECYKKKHPTILKTNHNDLDIPQIRIYKFNNKSNQRDAYINGGRSMISTSYFLSCRILPYLWSFYESYPTYKDIYTRLLQSSTQLTTYLDNLCVNLYETKNWQKMMNNFNNVHLESSVEIYDNRLIPYNQYIVLEYIWEYFINGNTMILIEKYISALIFSIYSSKKVGFFEVWLLLSLWKRYPARIYRHMMKTSSTWIVPFLMDHLIHYSILVKNNYIGISSPKNDLIRVFNNIELENTFSFLLYHYHPQYYHDRMSGKYFWYNASSEQGYLNKINSHNTEIKGLVMNCRYTQGNHQLVLQFHDYLHYIGHSLPFPVVIYLLSNQFSSEKKKFMSNSHHFHNYFHHSLYTSTLIVWSCVRSLLLSQESEWELLLLQYMEIIKSNKRNNQLVLTGLLDMALKSTRFSQILCIYTNNPNSPIMNIFQKSLFKECDFLLTCKSMKSSEENIERNEDQNMNGKYEKRNSSEIHGKGVINRLRTVQDSMEGLNLRMSSVSSLINKCFDTISETSENLNRSSLNILQFENKKHSLANVQFSFFYILCQLGEMAKYRNRKEGGLGLPIEEDDNPSALIGRLNSKEIAQLKSEIAQDLLAKIENVIQRKEYKNVPFLNTNMLKSSENKTKLLSIKKINKLKILQSAKNIPYLLSLQLTDHNSDNQDTLVDISKIEPEQDYEMTINLIVKCNDDCRQDVITMQYIHVFQKIFELYNIPVWLYPYRILPMMFKDINNSVIYGGIIEFIEDSISLHEIHELHSEGGLKAYYESTFGGKNSHIKKLENDNNVSYEQARYNFISSLAGYSIACYVLQIKDRHNGNILITKNGHIIHIDYGFIFDISPGNNLHFERAAFKVTQEMLDFMDDQVDLFDDLCLSGFLAVREHADLLLSLTQMLINSGIPCFRGETIKKLKERLLLNFSQQQASNIFSKKIHSAHNHITTKGYDLVQFIQQGIK
 
Inhibitor
Name:
BDBM533856
Synonyms:
Methyl 5-(3-(4-carbamoylphenyl)pyrazolo[1,5-a]pyridine-5-carboxamido)-2-chlorobenzoate (1.23) | WO2022079616, Example 1.23
Type:
Small organic molecule
Emp. Form.:
C23H17ClN4O4
Mol. Mass.:
448.858
SMILES:
COC(=O)c1cc(NC(=O)c2ccn3ncc(-c4ccc(cc4)C(N)=O)c3c2)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: