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Target
Mixed lineage kinase domain-like protein
Ligand
BDBM534285
Substrate
n/a
Meas. Tech.
MLKL Phosphorylation High-Content Assay
IC50
0.60±n/a nM
Citation
 Guanglin, L; Jie, C; Diane, DC; B., FD; Junqing, G; C., HA; Xirui, H; E., MM; Reiser, PM; Jianliang, S; H., SS; Lee, VB; Yong-Jin, W; Zili, X; G., YM TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Mixed lineage kinase domain-like protein
Synonyms:
MLKL | MLKL_HUMAN | Mixed lineage kinase domain-like protein | hMLKL
Type:
PROTEIN
Mol. Mass.:
54493.57
Organism:
Homo sapiens
Description:
ChEMBL_104428
Residue:
471
Sequence:
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
  
Inhibitor
Name:
BDBM534285
Synonyms:
3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-2-fluoro-6-methyl-N-(4,4,4-trifluoro-3-phenylbutyl)benzamide enantiomer 2 | WO2022086828, Example 13
Type:
Small organic molecule
Emp. Form.:
C24H21F4N5O
Mol. Mass.:
471.4501
SMILES:
Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCC[C@@H](c1ccccc1)C(F)(F)F |r|
Structure:
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