Target
Oxysterols receptor LXR-alpha
Ligand
BDBM304644
Substrate
n/a
Meas. Tech.
LXR alpha/beta Radioligand Binding Assay
Ki
32.0±n/a nM
Citation
 Claremon, DADong, CFan, YLeftheris, KLotesta, SDSingh, SBTice, CMZhao, WZheng, YZhuang, L Piperazine derivatives as liver X receptor modulators US Patent  US10144715 Publication Date 12/4/2018 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM304644
Synonyms:
(S)-2-(4-fluorophenyl)-4-(3-(methylsulfonyl)phenyl)-1-(((1R,3R)-3-(trifluoromethyl)cyclohexyl)methyl)piperazine | BDBM304645 | US10144715, Compound 48-39
Type:
Small organic molecule
Emp. Form.:
C24H27F4N3O3S
Mol. Mass.:
513.548
SMILES:
NS(=O)(=O)c1cccc(c1)N1CCN([C@H](C1)c1ccc(F)cc1)C(=O)C1CCC[C@H](C1)C(F)(F)F |r|
Structure:
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