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Target
Eukaryotic translation initiation factor 4E-binding protein 1
Ligand
BDBM544834
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
IC50
2.92±n/a nM
Citation
 Sperry, S; Xiang, AX; Ernst, JT; Reich, SH; Sprengeler, PA; Shaghafi, M; Michels, T; Nilewski, C; Tran, CV; Packard, GK; Grubbs, A; Urkalan, K; Mukaiyama, T EIF4E-inhibiting compounds and methods US Patent  US11286268 Publication Date 3/29/2022 
Target
Name:
Eukaryotic translation initiation factor 4E-binding protein 1
Synonyms:
4EBP1_HUMAN | EIF4EBP1 | GFP-4EBP | GFP-4EBP1 | Green fluorescent protein-Eukaryotic initiation factor 4E (eIF4E) binding protein
Type:
Fusion protein
Mol. Mass.:
12578.35
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
118
Sequence:
MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI
  
Inhibitor
Name:
BDBM544834
Synonyms:
US11286268, Compound 318
Type:
Small organic molecule
Emp. Form.:
C29H19ClF3N3O6S2
Mol. Mass.:
662.056
SMILES:
Cc1c(c2cc(cc(C#N)c2c(=O)n1CCOc1ccc(Cl)cc1-c1ccnc2c(csc12)C(O)=O)C(F)(F)F)S(C)(=O)=O
Structure:
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