Reaction Details Report a problem with these data
Target
GTPase KRas [1-169,G12C,C118A]
Ligand
BDBM548312
Substrate
n/a
IC50
472±n/a nM
Citation
 Alan, LB; Abhisek, B; Margaret, C; Dongcheng, D; R., KM; Patricia, L; Van, MV; Francesco, M; M., MJ; J., PA; A., TN; Kai, Z HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE WIPO 0:0 (2022) [PubMed] 
Target
Name:
GTPase KRas [1-169,G12C,C118A]
Synonyms:
GTPase KRas | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
PROTEIN
Mol. Mass.:
19407.24
Organism:
Homo sapiens (Human)
Description:
P01116[1-169,G12C,C118A]
Residue:
169
Sequence:
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKADLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLK
  
Inhibitor
Name:
BDBM548312
Synonyms:
WO2022093856, Example 1-9
Type:
Small organic molecule
Emp. Form.:
C25H37N7O3
Mol. Mass.:
483.6064
SMILES:
CNC(=O)C[C@H](CC(C)C)Nc1nc(nc2CN(Cc12)C(C)=O)N1CCC2(CN(C2)C(=O)C=C)C1 |r|
Structure:
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