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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM548846
Substrate
n/a
Meas. Tech.
HPK1-SLP76 TR-FRET ASSAY
IC50
0.03±n/a nM
Citation
 A., CD; L., CJ; Anthony, D; Xavier, F; H., FP; Shuhei, K; Bing, L; Jongwon, L; Ping, L; L., MJ; G., NA; Alexander, P; A., VB; C., YE 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 WIPO 0:0 (2022) [PubMed] 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM548846
Synonyms:
WO2022098806, Compound 2-107 | WO2022098806, Compound 2-184 | WO2022098806, Compound 2-185
Type:
Small organic molecule
Emp. Form.:
C26H24ClF2N7O
Mol. Mass.:
523.965
SMILES:
CN1CCc2cc(F)c(Nc3ncc4c(N)c(F)c(c(Cl)c4n3)-c3cnc4OCCNc4c3C)cc2C1 |(-1,-6.56,;-2.33,-5.79,;-3.66,-6.56,;-5,-5.79,;-5,-4.25,;-6.33,-3.47,;-6.33,-1.94,;-7.67,-1.17,;-5,-1.17,;-5,.37,;-3.66,1.14,;-3.66,2.68,;-2.33,3.45,;-1,2.68,;.33,3.45,;.33,4.99,;1.67,2.68,;3,3.45,;1.67,1.14,;.33,.37,;.33,-1.17,;-1,1.14,;-2.33,.37,;3,.37,;4.33,1.14,;5.67,.37,;5.67,-1.17,;7,-1.94,;7,-3.48,;5.67,-4.25,;4.34,-3.48,;4.33,-1.94,;3,-1.17,;1.67,-1.94,;-3.66,-1.94,;-3.66,-3.48,;-2.33,-4.25,)|
Structure:
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