Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM306067
Substrate
n/a
Meas. Tech.
NAMPT Enzyme Assay
IC50
300±n/a nM
Citation
 Gigstad, KM; Cardin, DP; Hirayama, T; Hirose, M; Hu, Y; Kakei, H; Lee, HM; Motoyaji, T; Nii, N; Shi, Z; Vyskocil, S; Watanabe, H Quinoxaline compounds and uses thereof US Patent  US10144742 Publication Date 12/4/2018 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM306067
Synonyms:
US10144742, Compound I-229
Type:
Small organic molecule
Emp. Form.:
C29H22F2N4O
Mol. Mass.:
480.508
SMILES:
Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ccncc1
Structure:
Search PDB for entries with ligand similarity: