Reaction Details Report a problem with these data
Target
Mast/stem cell growth factor receptor Kit [V560G,D816V]
Ligand
BDBM175668
Substrate
n/a
Meas. Tech.
Autophosphorylation Assay
Temperature
298.15±n/a K
IC50
55±n/a nM
Comments
extracted
Citation
 Hodous, BL Compositions useful for treating disorders related to kit US Patent  US9688680 Publication Date 6/27/2017 
Target
Name:
Mast/stem cell growth factor receptor Kit [V560G,D816V]
Synonyms:
KIT | KIT_HUMAN | SCFR | Tyrosine-protein kinase Kit (Kit)(V560G/D816V)
Type:
n/a
Mol. Mass.:
109812.35
Organism:
Homo sapiens (Human)
Description:
Human Kit V560G/D816V mutant
Residue:
976
Sequence:
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVGEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV
  
Inhibitor
Name:
BDBM175668
Synonyms:
US9688680, 214
Type:
Small organic molecule
Emp. Form.:
C29H33N5O2
Mol. Mass.:
483.6046
SMILES:
Cc1ccc(CNC(=O)C2(C)CN(C2)c2ncnn3cc(cc23)-c2ccc(OC(C)(C)C)cc2)cc1
Structure:
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