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Target
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ligand
BDBM309236
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
<10.00±n/a nM
Citation
 Amberg, W; Pohlki, F; Lange, U; Wang, YX; Zhao, HH; Li, H; Brewer, JT; Zanze, I; Dietrich, J; Vasudevan, A; Djuric, SW; Lao, Y; Hutchins, CW Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent  US9656955 Publication Date 5/23/2017 
Target
Name:
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:
GGNT1 | GLCT1 | GLYT1 | GNT-I | GlcNAc-T I | MGAT | MGAT1 | MGAT1_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
Type:
PROTEIN
Mol. Mass.:
50891.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107587
Residue:
445
Sequence:
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSAWNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN
  
Inhibitor
Name:
BDBM309236
Synonyms:
4-chloro-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]pyrrolidin-3-yl}pyridin-2-amine | US9656955, Example 759
Type:
Small Organic Molecule
Emp. Form.:
C19H19ClFN5O2S
Mol. Mass.:
435.903
SMILES:
Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(Cl)ccn2)[C@H](C1)c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: