Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM309925
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
Ki
496±n/a nM
Citation
 Buchholz, M; Heiser, U; Niestroj, AJ; Sommer, R Inhibitors of glutaminyl cyclase US Patent  US9656991 Publication Date 5/23/2017 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM309925
Synonyms:
1-(3,5- dimethoxyphenyl)-3- (3-(4-methyl-1H- imidazol-1- yl)propyl)thiourea | US9656991, 39
Type:
Small organic molecule
Emp. Form.:
C16H22N4O2S
Mol. Mass.:
334.436
SMILES:
COc1cc(NC(=S)NCCCn2cnc(C)c2)cc(OC)c1
Structure:
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