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Target
Caspase-3
Ligand
BDBM10251
Substrate
Caspase-3 Substrate
Meas. Tech.
Caspase Inhibition Assay
pH
7.5±n/a
Temperature
308.15±n/a K
IC50
544±16 nM
Citation
More Info.:
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Inhibitor
Name:
BDBM10251
Synonyms:
2-(2-phenylethyl)-1,2,3,4-tetrahydroisoquinoline-1,3,4-trione | 2-Phenethylisoquinoline-1,3,4-trione | Isoquinoline-1,3,4-trione 2d
Type:
Small organic molecule
Emp. Form.:
C17H13NO3
Mol. Mass.:
279.29
SMILES:
O=C1N(CCc2ccccc2)C(=O)c2ccccc2C1=O
Substrate
Name:
Caspase-3 Substrate
Synonyms:
Caspase-3 Substrate (Chromogenic)
Type:
n/a
Mol. Mass.:
1438.65
Organism:
n/a
Description:
pNA=p-Nitroaniline
Residue:
16
Sequence:
ACASPGLVALASPPNA