Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM313646
Substrate
n/a
Meas. Tech.
In Vitro Raf Activity Determination
IC50
50.0±n/a nM
Citation
 Aversa, RJBurger, MTDillon, MPDineen, Jr., TALou, YNishiguchi, GARamurthy, SRico, ACRauniyar, VSendzik, MSubramanian, SSetti, LQTaft, BRTanner, HRWan, L Compounds and compositions as RAF kinase inhibitors US Patent  US10167279 Publication Date 1/1/2019 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM313646
Synonyms:
N-(3-(2-(2- hydroxyethoxy)-6- (tetrahydro-2H-pyran-4- yl)pyridin-4-yl)-4- methylphenyl)-4- (trifluoromethyl) picolinamide | US10167279, Example 272
Type:
Small organic molecule
Emp. Form.:
C26H26F3N3O4
Mol. Mass.:
501.4975
SMILES:
Cc1ccc(NC(=O)c2cc(ccn2)C(F)(F)F)cc1-c1cc(OCCO)nc(c1)C1CCOCC1
Structure:
Search PDB for entries with ligand similarity: