Target
Amine oxidase [flavin-containing] B
Ligand
BDBM10829
Substrate
BDBM10758
Meas. Tech.
Cholinesterase Inhibition Assay
IC50
240±n/a nM
Citation
 Sterling, JHerzig, YGoren, TFinkelstein, NLerner, DGoldenberg, WMiskolczi, IMolnar, SRantal, FTamas, TToth, GZagyva, AZekany, AFinberg, JLavian, GGross, AFriedman, RRazin, MHuang, WKrais, BChorev, MYoudim, MBWeinstock, M Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. J Med Chem 45:5260-79 (2002) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rattus norvegicus (rat)
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
  
Inhibitor
Name:
BDBM10829
Synonyms:
3-(N-Methyl,Ncyclohexylcarbamyloxy)-N-methyl-N-propargylphenylpropylamine Mesylate | 3-{2-[methyl(prop-2-yn-1-yl)amino]propyl}phenyl N-cyclohexyl-N-methylcarbamate; methanesulfonic acid | Phenethylamine deriv. 53e
Type:
Small organic molecule
Emp. Form.:
C21H30N2O2
Mol. Mass.:
342.4751
SMILES:
CC(Cc1cccc(OC(=O)N(C)C2CCCCC2)c1)N(C)CC#C
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10758
Synonyms:
14C-phenylethylamine | 2-phenylethan-1-amine | CHEMBL610 | phenylethylamine
Type:
Small organic molecule
Emp. Form.:
C8H11N
Mol. Mass.:
121.1796
SMILES:
NCCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: