Target
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Ligand
BDBM188335
Substrate
n/a
Meas. Tech.
Raf IC50 Assay
Temperature
298.15±n/a K
IC50
150±n/a nM
Comments
extracted
Citation
 Zhou, CZhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent  US9670203 Publication Date 6/6/2017 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Synonyms:
C-Raf (Y340D/Y341D) | RAF | RAF1 | RAF1_HUMAN
Type:
n/a
Mol. Mass.:
38958.87
Organism:
Homo sapiens (Human)
Description:
PV3805, from Invitrogen
Residue:
343
Sequence:
SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM188335
Synonyms:
US9670203, Compound 1.41
Type:
Small organic molecule
Emp. Form.:
C24H19FN4O4
Mol. Mass.:
446.4305
SMILES:
Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: