Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase B-raf [416-766,V600E]
Ligand
BDBM191048
Substrate
n/a
Meas. Tech.
Raf IC50 Assay
Temperature
298.15±n/a K
IC50
2600±n/a nM
Comments
extracted
Citation
 Zhou, C; Zhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent  US9670203 Publication Date 6/6/2017 
Target
Name:
Serine/threonine-protein kinase B-raf [416-766,V600E]
Synonyms:
B-Raf (V600E) | BRAF | BRAF1 | BRAF_HUMAN | RAFB1
Type:
n/a
Mol. Mass.:
39690.71
Organism:
Homo sapiens (Human)
Description:
PV3849, from Invitrogen
Residue:
351
Sequence:
LQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM191048
Synonyms:
US9670203, Compound 2.3 1-((1S,1aS,6bS)-5-((2-oxo-2,4-dihydro-1H-pyrido[2,3-d][1,3] oxazin-5-yl)oxy)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-yl)-3-(2,4,5-trifluorophenyl)urea
Type:
Small organic molecule
Emp. Form.:
C23H15F3N4O5
Mol. Mass.:
484.3842
SMILES:
Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)OCc56)cc4[C@@H]23)cc1F |r|
Structure:
Search PDB for entries with ligand similarity: