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Target
Serine/threonine-protein kinase B-raf [416-766,V600E]
Ligand
BDBM191338
Substrate
n/a
Meas. Tech.
Raf IC50 Assay
Temperature
298.15±n/a K
IC50
26000±n/a nM
Comments
extracted
Citation
 Zhou, C; Zhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent  US9670203 Publication Date 6/6/2017 
Target
Name:
Serine/threonine-protein kinase B-raf [416-766,V600E]
Synonyms:
B-Raf (V600E) | BRAF | BRAF1 | BRAF_HUMAN | RAFB1
Type:
n/a
Mol. Mass.:
39690.71
Organism:
Homo sapiens (Human)
Description:
PV3849, from Invitrogen
Residue:
351
Sequence:
LQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM191338
Synonyms:
US9670203, Compound 2.6 N-methyl-4-(((1S,1aS,6bS)-1-(3-(3-(trifluoromethyl)phenyl) ureido)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)picolinamide
Type:
Small organic molecule
Emp. Form.:
C24H19F3N4O4
Mol. Mass.:
484.4273
SMILES:
CNC(=O)c1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5cccc(c5)C(F)(F)F)[C@@H]4c3c2)ccn1 |r|
Structure:
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