Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 1 [8-360]
Ligand
BDBM193405
Substrate
n/a
Meas. Tech.
ERK-2 Enzymatic Assay
pH
7.3±n/a
IC50
2.70±n/a nM
Comments
extracted
Citation
 Blake, JF; Cook, A; Gaudino, J; Gunawardana, IW; Hicken, EJ; Hunt, KW; Lyon, M; Metcalf, AT; Mohr, PJ; Moreno, DA; Newhouse, B; Ren, L; Schwarz, J; Chen, H; Gazzard, L; Schmidt, J; Do, S Serine/threonine kinase inhibitors US Patent  US9670208 Publication Date 6/6/2017 
Target
Name:
Mitogen-activated protein kinase 1 [8-360]
Synonyms:
ERK2 | Human ERK-2 | MAPK1 | MK01_HUMAN | Mitogen Activated Kinase 1 | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (aa 8-360) | PRKM1 | PRKM2
Type:
n/a
Mol. Mass.:
40835.09
Organism:
Homo sapiens (Human)
Description:
P28482 aa 8-360
Residue:
353
Sequence:
GAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM193405
Synonyms:
US9670208, Example 169 4-(3-isobutyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-(1-methyl-1H-pyrazol-5-yl)pyrimidin-2-amine
Type:
Small organic molecule
Emp. Form.:
C18H20N8
Mol. Mass.:
348.405
SMILES:
CC(C)Cc1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1
Structure:
Search PDB for entries with ligand similarity: