Target
Mitogen-activated protein kinase 1 [8-360]
Ligand
BDBM193675
Substrate
n/a
Meas. Tech.
ERK-2 Enzymatic Assay
pH
7.3±n/a
IC50
0.60±n/a nM
Comments
extracted
Citation
 Blake, JFCook, AGaudino, JGunawardana, IWHicken, EJHunt, KWLyon, MMetcalf, ATMohr, PJMoreno, DANewhouse, BRen, LSchwarz, JChen, HGazzard, LSchmidt, JDo, S Serine/threonine kinase inhibitors US Patent  US9670208 Publication Date 6/6/2017 
Target
Name:
Mitogen-activated protein kinase 1 [8-360]
Synonyms:
ERK2 | Human ERK-2 | MAPK1 | MK01_HUMAN | Mitogen Activated Kinase 1 | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (aa 8-360) | PRKM1 | PRKM2
Type:
n/a
Mol. Mass.:
40835.09
Organism:
Homo sapiens (Human)
Description:
P28482 aa 8-360
Residue:
353
Sequence:
GAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM193675
Synonyms:
US9670208, Example 279 N-(1-methyl-1H-pyrazol-5-yl)-4-(3-neopentyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl)pyridin-2-amine
Type:
Small organic molecule
Emp. Form.:
C20H23N7
Mol. Mass.:
361.4435
SMILES:
Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC(C)(C)C)nnc2c1
Structure:
Search PDB for entries with ligand similarity: