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Target
Mu-type opioid receptor
Ligand
BDBM327436
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1.30±n/a nM
Citation
 Taniko, K; Miyazawa, T; Kaneko, T; Kurumazuka, D; Harada, S; Izuchi, T; Okabe, M; Iwamura, R; Tsuzaki, Y; Setoguchi, H; Imura, Y; Akaza, H; Shimizu, M; Kimura, T 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose US Patent  US9663463 Publication Date 5/30/2017 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM327436
Synonyms:
N-(3-{(1R,5S,6r)-3-[3-(1-ethoxy-4,4-difluorocyclohexyl)propyl]-6-ethyl-3-azabicyclo[3.1.0]hexan-6-yl}phenyl)cyclopropanesulfonamide | US9663463, 14-(b)
Type:
Small organic molecule
Emp. Form.:
C27H40F2N2O3S
Mol. Mass.:
510.68
SMILES:
CCOC1(CCCN2C[C@H]3[C@@H](C2)C3(CC)c2cccc(NS(=O)(=O)C3CC3)c2)CCC(F)(F)CC1
Structure:
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