Target

Ligand

Substrate

Meas. Tech.

PKB In Vitro Kinase Assay

pH

7.5±n/a

Temperature

295.15±n/a K

Citation

 Breitenlechner, CB; Friebe, WG; Brunet, E; Werner, G; Graul, K; Thomas, U; Kunkele, KP; Schafer, W; Gassel, M; Bossemeyer, D; Huber, R; Engh, RA; Masjost, B Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants. J Med Chem 48:163-70 (2005) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

RAC-alpha serine/threonine-protein kinase

Synonyms:

AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)

Type:

Enzyme

Mol. Mass.:

55681.25

Organism:

Homo sapiens (Human)

Description:

P31749

Residue:

480

Sequence:

MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM11820

Synonyms:

(3R,4R)-N-(4-{4-[5-(3,3-dimethylpiperidin-1-yl)-2-hydroxybenzoyl]benzoylamino}azepan-3-yl)isonicotinamide hydrochloride | N-[(3R,4R)-4-[(4-{[5-(3,3-dimethylpiperidin-1-yl)-2-hydroxyphenyl]carbonyl}benzene)amido]azepan-3-yl]pyridine-4-carboxamide hydrochloride | Protein Kinase B-Selective Inhibitor 4

Type:

Small organic molecule

Emp. Form.:

C33H39N5O4

Mol. Mass.:

569.6939

SMILES:

CC1(C)CCCN(C1)c1ccc(O)c(c1)C(=O)c1ccc(cc1)C(=O)N[C@@H]1CCCNC[C@H]1NC(=O)c1ccncc1 |r|

Structure:

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Similarity to this molecule at least:

Name:

Biotinylated Peptide Substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

1764.91

Organism:

n/a

Description:

n/a

Residue:

17

Sequence:

ITINSGRARTSSFAEPG