Reaction Details Report a problem with these data
Target
Cystathionine gamma-lyase
Ligand
BDBM330317
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
<10000±n/a nM
Citation
 Durón, SG; Chapman, J; Sydserff, SG; Rao, SG; Stein, G; Wade, W Cystathionine-γ-lyase (CSE) inhibitors US Patent  US9725426 Publication Date 8/8/2017 
Target
Name:
Cystathionine gamma-lyase
Synonyms:
CGL_HUMAN | CTH | Cystathionine gamma-lyase (CSE) | Cysteine-protein sulfhydrase | Gamma-cystathionase
Type:
Protein
Mol. Mass.:
44509.52
Organism:
Homo sapiens (Human)
Description:
P32929
Residue:
405
Sequence:
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
  
Inhibitor
Name:
BDBM330317
Synonyms:
US9725426, 21
Type:
Small organic molecule
Emp. Form.:
C4H8N6
Mol. Mass.:
140.1465
SMILES:
CC(C)=NNc1nnn[nH]1 |(3.85,.15,;2.52,-.62,;2.52,-2.16,;1.18,.15,;-.15,-.62,;-1.48,.15,;-2.95,-.33,;-3.85,.92,;-2.95,2.16,;-1.48,1.69,)|
Structure:
Search PDB for entries with ligand similarity: