Target
Stromelysin-1
Ligand
BDBM13098
Substrate
Substance P
Meas. Tech.
Enzyme Inhibition Assay
Ki
94±n/a nM
Citation
 MacPherson, LJBayburt, EKCapparelli, MPCarroll, BJGoldstein, RJustice, MRZhu, LHu, SMelton, RAFryer, LGoldberg, RLDoughty, JRSpirito, SBlancuzzi, VWilson, DO'Byrne, EMGanu, VParker, DT Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J Med Chem 40:2525-32 (1997) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM13098
Synonyms:
CGS 27023A Analog 26 | N-hydroxy-2-[(4-methoxybenzene)(3-methylbutyl)sulfonamido]acetamide
Type:
Small organic molecule
Emp. Form.:
C14H22N2O5S
Mol. Mass.:
330.4
SMILES:
COc1ccc(cc1)S(=O)(=O)N(CCC(C)C)CC(=O)NO
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Substance P
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
3656.51
Organism:
n/a
Description:
n/a
Residue:
32
Sequence:
ARGPRLYSPRGLNGLNPHEPHEGLYLEMETNH