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Reaction Details
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TargetCoagulation factor VII
LigandBDBM13591
Substrate/CompetitorBDBM13553
Meas. Tech.Serine Protease Inhibition Assay
pH7.8±n/a
Temperature295.15±n/a K
Ki 35±n/a nM
Citation Groebke Zbinden, KBanner, DWHilpert, KHimber, JLave, TRiederer, MAStahl, MTschopp, TBObst-Sander, U Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity. Bioorg Med Chem14:5357-69 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Coagulation factor VII
Name:Thrombin and coagulation factor VII
Synonyms:Eptacog alfa | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | serum prothrombin conversion accelerator
Type:Enzyme
Mol. Mass.:51599.89
Organism:Homo sapiens (Human)
Description:n/a
Residue:466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM13591
NameBDBM13591
Synonyms:(2R)-2-[(4-carbamimidoylphenyl)amino]-2-{5-ethoxy-2-fluoro-3-[(3S)-oxolan-3-yloxy]phenyl}acetic acid | (R)-(4-Carbamimidoyl-phenylamino)-{3-ethoxy-2-fluoro-5-[(S)-(tetra-hydro-furan-3-yl)-oxy]-phenyl}-acetic acid | phenylglycine derivative 6
TypeSmall organic molecule
Emp. Form.C21H24FN3O5
Mol. Mass.417.4308
SMILESCCOc1cc(O[C@H]2CCOC2)c(F)c(c1)[C@@H](Nc1ccc(cc1)C(N)=N)C(O)=O |r|
Structure
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BDBM13553
NameBDBM13553
Synonyms:(2S)-5-carbamimidamido-2-{2-[(2R)-2-methanesulfonamido-3-phenylpropanamido]acetamido}-N-(4-nitrophenyl)pentanamide; acetic acid | Chromozym tPA | N-Methylsulfonyl-D-Phe-Gly-Arg-4-nitranilide acetate
TypeSmall organic molecule
Emp. Form.C24H32N8O7S
Mol. Mass.576.625
SMILESCS(=O)(=O)N[C@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure
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