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Target
Dimer of Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Ligand
BDBM580
Substrate
HIV Protease Chromogenic Peptide Substrate
Meas. Tech.
Protease Inhibition Assay
Ki
9.4±n/a nM
Citation
 Clemente, JC; Moose, RE; Hemrajani, R; Whitford, LR; Govindasamy, L; Reutzel, R; McKenna, R; Agbandje-McKenna, M; Goodenow, MM; Dunn, BM Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease. Biochemistry 43:12141-51 (2004) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Synonyms:
HIV-1 Protease Mutant V6(54/84) | HIV-1 protease mutant (K20R V32I L33F M36I I54V L63P A71V V82A I84V L90M)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
The post-ritonavir therapy protease variant plus I54V/I84V mutations, which were created by site-directed mutagenesis.
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Synonyms:
HIV-1 Protease Mutant V6(54/84) chain A | HIV-1 Protease Mutant V6(54/84) chain B | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10813.12
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF
  
Component 2
Name:
Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Synonyms:
HIV-1 Protease Mutant V6(54/84) chain A | HIV-1 Protease Mutant V6(54/84) chain B | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10813.12
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,I573V,L579M]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF
  
Inhibitor
Name:
BDBM580
Synonyms:
(4R)-3-[(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-phenylbutanoyl]-5,5-dimethyl-N-[(2-methylphenyl)methyl]-1,3-thiazolidine-4-carboxamide | AG1776 | BDBM50288366 | JE-2147 | KNI-764
Type:
Small organic molecule
Emp. Form.:
C32H37N3O5S
Mol. Mass.:
575.718
SMILES:
Cc1ccccc1CNC(=O)[C@H]1N(CSC1(C)C)C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(O)c1C |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
HIV Protease Chromogenic Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1420.11
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
KARVLNPHEANLG