Reaction Details
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Report a problem with these dataTarget
Mitogen-activated protein kinase 14
Ligand
BDBM5718
Substrate
Substrate Peptide T669
Meas. Tech.
Kinase Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
>100000±n/a nM
Citation
Wang, Z; Canagarajah, BJ; Boehm, JC; Kassisa, S; Cobb, MH; Young, PR; Abdel-Meguid, S; Adams, JL; Goldsmith, EJ Structural basis of inhibitor selectivity in MAP kinases. Structure 6:1117-28 (1998) [PubMed] Article Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Inhibitor
Name:
BDBM5718
Synonyms:
2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol | 2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol | 6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-methylpurine | CHEMBL280074 | Olomoucine | purine deriv. 5
Type:
Small organic molecule
Emp. Form.:
C15H18N6O
Mol. Mass.:
298.343
SMILES:
Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12
Structure:
Substrate
Name:
Substrate Peptide T669
Synonyms:
epidermal growth factor receptor (EGFR) derived peptide T669
Type:
Peptide
Mol. Mass.:
2317.55
Organism:
n/a
Description:
n/a
Residue:
21
Sequence:
ERELVEPLTPSGEAPNQALLR