Reaction Details Report a problem with these data
Target
A-kinase anchor protein 7 isoform gamma
Ligand
BDBM212758
Substrate
n/a
Meas. Tech.
Binding Assay
EC50
2500±0 nM
Citation
 Tasken, K; Lygren, B; Ostensen, E; Klaveness, J Tertiary amines for use in the treatment of cardiac disorders US Patent  US9556111 Publication Date 1/31/2017 
Target
Name:
A-kinase anchor protein 7 isoform gamma
Synonyms:
A-kinase anchor protein 18 kDa | AKA7G_HUMAN | AKAP 18 | AKAP-7 isoform gamma | AKAP18 | AKAP7 | PRKA7 isoform gamma | Protein kinase A-anchoring protein 7 isoform gamma
Type:
Protein
Mol. Mass.:
39515.45
Organism:
Homo sapiens (Human)
Description:
Q9P0M2
Residue:
348
Sequence:
MERPEAGGINSNECENVSRKKKMSEEFEANTMDSLVDMPFATVDIQDDCGITDEPQINLKRSQENEWVKSDQVKKRKKKRKDYQPNYFLSIPITNKEIIKGIKILQNAIIQQDERLAKAMVSDGSFHITLLVMQLLNEDEVNIGIDALLELKPFIEELLQGKHLTLPFQGIGTFGNQVGFVKLAEGDHVNSLLEIAETANRTFQEKGILVGESRSFKPHLTFMKLSKSPWLRKNGVKKIDPDLYEKFISHRFGEEILYRIDLCSMLKKKQSNGYYHCESSIVIGEKNGGEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGEGSSVKTEAADQNGNDNENNRK
  
Inhibitor
Name:
BDBM212758
Synonyms:
US9556111, Table 1.23 | US9951033, Compound Table 1.21
Type:
Small organic molecule
Emp. Form.:
C37H37N5O2
Mol. Mass.:
583.722
SMILES:
Cc1ccc(NC(=O)Nc2ccc(CN(Cc3ccccc3)Cc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)cc2)cc1
Structure:
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