Target
Chymase
Ligand
BDBM16127
Substrate
BDBM16302
Meas. Tech.
Enzyme Inhibition Assay
pH
8.2±n/a
Temperature
295.15±n/a K
Ki
>1000000±n/a nM
Citation
 Katz, BAClark, JMFiner-Moore, JSJenkins, TEJohnson, CRRoss, MJLuong, CMoore, WRStroud, RM Design of potent selective zinc-mediated serine protease inhibitors. Nature 391:608-12 (1998) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM16127
Synonyms:
2,2 -methanediylbis(1H-benzimidazole-6-carboximidamide) | 2-[(6-carbamimidoyl-1H-1,3-benzodiazol-2-yl)methyl]-1H-1,3-benzodiazole-6-carboximidamide | AIDS007118 | BABIM | CHEMBL542712 | CHEMBL99951
Type:
Small organic molecule
Emp. Form.:
C17H16N8
Mol. Mass.:
332.3625
SMILES:
NC(=N)c1ccc2nc(Cc3nc4ccc(cc4[nH]3)C(N)=N)[nH]c2c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM16302
Synonyms:
Chymase/Chymotrypsin Chromogenic Substrate | Suc-Val-Pro-Phe-SBzl
Type:
Small organic molecule
Emp. Form.:
C30H37N3O6S
Mol. Mass.:
567.696
SMILES:
CC(C)[C@H](NC(=O)CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)SCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: