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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM16636
Substrate
BDBM16443
Meas. Tech.
In Vitro Aldose Reductase Inhibition Assay
IC50
6±n/a nM
Citation
 Mylari, BL; Armento, SJ; Beebe, DA; Conn, EL; Coutcher, JB; Dina, MS; O'Gorman, MT; Linhares, MC; Martin, WH; Oates, PJ; Tess, DA; Withbroe, GJ; Zembrowski, WJ A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners. J Med Chem 48:6326-39 (2005) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM16636
Synonyms:
6-[(5-chloro-3-ethyl-1-benzofuran-2-)sulfonyl]-2,3-dihydropyridazin-3-one | Heterocyclic Sulfonylpyridazinone, 19r
Type:
Small organic molecule
Emp. Form.:
C14H11ClN2O4S
Mol. Mass.:
338.766
SMILES:
CCc1c(oc2ccc(Cl)cc12)S(=O)(=O)c1ccc(=O)[nH]n1
Structure:
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Substrate
Name:
BDBM16443
Synonyms:
(2R)-2,3-dihydroxypropanal | D-glyceraldehyde | Triose
Type:
Small organic molecule
Emp. Form.:
C3H6O3
Mol. Mass.:
90.0779
SMILES:
OC[C@@H](O)C=O
Structure:
Search PDB for entries with ligand similarity: