Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetXIAP-BIR3
LigandBDBM17344
Substrate/CompetitorBDBM17342
Meas. Tech.Fluorescence Polarization Affinity Measurements.
pH7.2±n/a
Temperature295.15±n/a K
Ki 50±n/a nM
Citation Zobel, KWang, LVarfolomeev, EFranklin, MCElliott, LOWallweber, HJOkawa, DCFlygare, JAVucic, DFairbrother, WJDeshayes, K Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol1:525-33 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
XIAP-BIR3
Name:XIAP-BIR3
Synonyms:BIR3 domain of X-linked inhibitor of apoptosis protein | baculovirus IAP repeat 3 (BIR3) domain of XIAP
Type:Protein Binding Domain
Mol. Mass.:13407.81
Organism:Homo sapiens (Human)
Description:BIR3 of XIAP: RESIDUES 241-356.
Residue:117
Sequence:
MSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVK
CFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM17344
NameBDBM17344
Synonyms:(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylbutanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanoic acid | AVPW | L-alanyl-L-valyl-L-prolyl-L-tryptophan
TypePolypeptide
Emp. Form.C24H33N5O5
Mol. Mass.471.5493
SMILESCC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
BDBM17342
NameBDBM17342
Synonyms:5-carboxyflourescein(5-FAM)-conjugated AVPFFAKK | AVP-diPhe-FAM
TypeFluorescent dye-conjugated peptide
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure