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Target
C-X-C chemokine receptor type 3
Ligand
BDBM228198
Substrate
n/a
Meas. Tech.
Receptor Internalization Assay (RIA)
IC50
462±n/a nM
Citation
 Caroff, E; Meyer, E (R)-2-methyl-piperazine derivatives as CXCR3 receptor modulators US Patent  US10047080 Publication Date 8/14/2018 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
  
Inhibitor
Name:
BDBM228198
Synonyms:
1-{(R)-4-[4-(2-Cyclopropyl-pyrimidin-5-yl)-2-trifluoromethyl-thiazol-5-yl]-2-methyl-piperazin-1-yl}-2-(3-methyl-[1,2,4]triazol-1-yl)-ethanone | US10047080, 21
Type:
Small organic molecule
Emp. Form.:
C22H24F3N7OS
Mol. Mass.:
491.532
SMILES:
CC1CNCC(N1C(=O)Cn1cnc(C)n1)c1sc(cc1-c1cnc(nc1)C1CC1)C(F)(F)F
Structure:
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