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Target
Glycine--tRNA ligase
Ligand
BDBM18138
Substrate
BDBM18133
Meas. Tech.
In Vitro Enzyme Activity Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
50±n/a nM
IC50
2000±n/a nM
Kd
270±80 nM
Citation
 Dignam, JD; Nada, S; Chaires, JB Thermodynamic characterization of the binding of nucleotides to glycyl-tRNA synthetase. Biochemistry 42:5333-40 (2003) [PubMed]  Article 
Target
Name:
Glycine--tRNA ligase
Synonyms:
GARS_BOMMO | GlyRS | Glycine--tRNA ligase | Glycyl-tRNA synthetase | tRNA synthetase (GlyRS)
Type:
Enzyme
Mol. Mass.:
76917.70
Organism:
Bombyx mori
Description:
B. mori glycyltRNA synthetase was expressed in E. coli.
Residue:
680
Sequence:
MADPKIEEILAPLRANVKEQGDLVRKLKEEKAPEIDIKKAVAELKTRKKILEDKELSLAPAEDLFDRAKMEDLIKRRFFYDQSFAIYGGITGQFDFGPMGCALKSNMIHLWKKFFILQEQMLEVECSILTPEPVLKASGHVERFADLMTKDIKTGECFRLDHLIKGHLEKIKSDKNTKIELKAEIEDILIKLDGMNADEMSALMKRFEMKSPISGNDLTPPIEFNLMFNTQIGPSGLVKGFLRPETAQGIFVNFKRLLEFNQGRLPFAAAQIGNSFRNEISPRSGLLRVREFTMCEIEHFCDVKEHPKFESVKNTQSLLYSADNQEQGKPADLTTIGDAVCKGIVNNETLGYFMARIHMYMLAVGIDPKRLRFRQHMGNEMAHYACDCWDAECLSSYGWIECVGCADRSAYDLTQHTKATGIRLAAEKKLPAPKQIEVVEAIANNGRIGKAFKKDSQAINDTLATLDNAALEEMQKELDSNGEYTLITARGEFKLTPSLVNVKKTQKTIHVEEIIPSVIEPSFGVGRILYCILEHNFRMREGDEQRTYFSLPPTVAPMKCVVLPLSGNAEFQPFVRDLSQELITVDVSHKVDDSSGSIGRRYARTDELGVPYAVTVDFDTIKEPHTVTLRERDSMRQVRLPMADVPTVVRDLSNSKILWSDVEQKYPKFEQQETVKGTSV
  
Inhibitor
Name:
BDBM18138
Synonyms:
2-amino-1-[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}sulfonyl)amino]ethan-1-one | 5-O-[N-(L-glycyl)sulfamoyl]adenosine | GSAd | Glycine sulfamoyl adenosine
Type:
Nucleoside or nucleotide
Emp. Form.:
C12H17N7O7S
Mol. Mass.:
403.371
SMILES:
NCC(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM18133
Synonyms:
2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Glycine
Type:
Amino Acid
Emp. Form.:
C2H5NO2
Mol. Mass.:
75.0666
SMILES:
NCC(O)=O
Structure:
Search PDB for entries with ligand similarity: