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Target
Protein-lysine 6-oxidase
Ligand
BDBM18359
Substrate
BDBM18365
Meas. Tech.
In Vitro Enzyme Inhibition
pH
4.5±n/a
Temperature
310.15±n/a K
IC50
28000±n/a nM
Citation
 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease. Bioorg Med Chem 14:7736-44 (2006) [PubMed]  Article 
Target
Name:
Protein-lysine 6-oxidase
Synonyms:
LOX | LYOX_HUMAN | Lysyl oxidase | alpha-Glucosidase (alpha-Glu)
Type:
PROTEIN
Mol. Mass.:
46954.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_306619
Residue:
417
Sequence:
MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
  
Inhibitor
Name:
BDBM18359
Synonyms:
(2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-methylpiperidine-3,4,5-triol | CHEMBL503021 | alpha-1-C-Methyl-DNJ
Type:
natural product
Emp. Form.:
C7H15NO4
Mol. Mass.:
177.1983
SMILES:
C[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM18365
Synonyms:
4-Methylumbelliferyl alpha-D-glucopyranoside | 4-methyl-7-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2H-chromen-2-one | 4-methylumbelliferyl alpha-glucoside
Type:
Small organic molecule
Emp. Form.:
C16H18O8
Mol. Mass.:
338.3093
SMILES:
Cc1cc(=O)oc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12
Structure:
Search PDB for entries with ligand similarity: