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Target
Mitogen-activated protein kinase 1
Ligand
BDBM243983
Substrate
n/a
Meas. Tech.
Activated ERK2 Kinase Assay
pH
7.5±n/a
IC50
839±n/a nM
Comments
extracted
Citation
 Dillon, MP; Lindvall, M; Poon, D; Ramurthy, S; Rauniyar, V; Shafer, C; Subramanian, S; Tanner, HR Substituted pyrrolo[3,4-d]pyrimidines as kinase inhibitors US Patent  US9546173 Publication Date 1/17/2017 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM243983
Synonyms:
US9546173, cmpd 59 | n-((s)-2-hydroxy-1-phenylethyl)-2-(((1r,3s)-3-hydroxycyclobutyl)amino)-5,5-dimethyl-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide
Type:
Small organic molecule
Emp. Form.:
C21H27N5O3
Mol. Mass.:
397.4708
SMILES:
CC1(C)N(Cc2nc(N[C@H]3C[C@H](O)C3)ncc12)C(=O)N[C@H](CO)c1ccccc1 |r,wU:9.8,wD:20.22,11.11,(-1.41,4.69,;-.64,3.35,;.13,4.69,;.26,2.11,;-.64,.86,;-2.1,1.34,;-3.44,.57,;-4.77,1.34,;-6.11,.57,;-6.11,-.97,;-5.02,-2.06,;-6.11,-3.15,;-6.11,-4.69,;-7.19,-2.06,;-4.77,2.88,;-3.44,3.65,;-2.1,2.88,;1.8,2.11,;2.57,3.44,;2.57,.78,;4.11,.78,;4.88,2.11,;6.42,2.11,;4.88,-.56,;4.11,-1.89,;4.88,-3.23,;6.42,-3.23,;7.19,-1.89,;6.42,-.56,)|
Structure:
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