Target
Mitogen-activated protein kinase 1
Ligand
BDBM243989
Substrate
n/a
Meas. Tech.
Activated ERK2 Kinase Assay
pH
7.5±n/a
IC50
8827±n/a nM
Comments
extracted
Citation
 Dillon, MPLindvall, MPoon, DRamurthy, SRauniyar, VShafer, CSubramanian, STanner, HR Substituted pyrrolo[3,4-d]pyrimidines as kinase inhibitors US Patent  US9546173 Publication Date 1/17/2017 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM243989
Synonyms:
(s)-methyl 3-((6-(((s)-2-hydroxy-1-phenylethyl)carbamoyl)-5,5-dimethyl-6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidin-2-yl)amino)pyrrolidine-1-carboxylate | US9546173, cmpd 65
Type:
Small organic molecule
Emp. Form.:
C23H30N6O4
Mol. Mass.:
454.5221
SMILES:
COC(=O)N1CC[C@@H](C1)Nc1ncc2c(CN(C(=O)N[C@H](CO)c3ccccc3)C2(C)C)n1 |r|
Structure:
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