Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM19759
Substrate
BDBM19963
Meas. Tech.
Enzyme Inhibition Assay
IC50
969±n/a nM
Citation
Altmann, E; Aichholz, R; Betschart, C; Buhl, T; Green, J; Lattmann, R; Missbach, M Dipeptide nitrile inhibitors of cathepsin K. Bioorg Med Chem Lett 16:2549-54 (2006) [PubMed] Article
More Info.:
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Inhibitor
Name:
BDBM19759
Synonyms:
benzyl N-[(1S)-1-{[(1R)-2-(benzyloxy)-1-cyanoethyl]carbamoyl}-3-methylbutyl]carbamate | dipeptidyl nitrile, 5h
Type:
Small organic molecule
Emp. Form.:
C24H29N3O4
Mol. Mass.:
423.5048
SMILES:
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](COCc1ccccc1)C#N |r|