Target
Thymidine phosphorylase
Ligand
BDBM20042
Substrate
BDBM1
Meas. Tech.
Enzyme Inhibition Assay
pH
6.4±n/a
Temperature
310.15±n/a K
IC50
9500±300 nM
Citation
 Nencka, RVotruba, IHrebabecký, HTloust'ová, EHorská, KMasojídková, MHolý, A Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett 16:1335-7 (2006) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase
Type:
Enzyme
Mol. Mass.:
49948.87
Organism:
Homo sapiens (Human)
Description:
The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319).
Residue:
482
Sequence:
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
  
Inhibitor
Name:
BDBM20042
Synonyms:
5-chloro-6-(pyrrolidin-1-yl)-1,3-diazinane-2,4-dione | uracil, 12
Type:
Small organic molecule
Emp. Form.:
C8H10ClN3O2
Mol. Mass.:
215.637
SMILES:
Clc1c([nH]c(=O)[nH]c1=O)N1CCCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM1
Synonyms:
dT | thymidine
Type:
Nucleoside or nucleotide
Emp. Form.:
C10H14N2O5
Mol. Mass.:
242.2286
SMILES:
Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: