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Target
Kappa-type opioid receptor
Ligand
BDBM364547
Substrate
n/a
Meas. Tech.
kappa-Opioid Receptor Binding Assay
Ki
0.026±0.00 nM
Citation
 Youngman, M Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans US Patent  US9862726 Publication Date 1/9/2018 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM364547
Synonyms:
(4bR,6S,8aS,9R)-N-benzyl-11- (cyclopropylmethyl)-3-methoxy- 5,6,7,8,9,10- hexahydro-9,4b-(epiminoethano)- 8a,6-(epoxymethano)phenanthren-6-amine | US9862726, Compound 10
Type:
Small organic molecule
Emp. Form.:
C29H36N2O2
Mol. Mass.:
444.6083
SMILES:
COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC5(CC[C@@]34OC5)NCc3ccccc3)c2c1 |r,TLB:9:8:20:31.5.6|
Structure:
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